Neuroendocrine markers
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Neuroendocrine markers are immunostains that suggest neuroendocrine differentiation.
Common markers
- Chromogranin A.
- Considered the most specific neuroendocrine stain.[1]
- Synaptophysin +ve.
- CD56.
- Less specific than chromogranin A and synaptophysin.
Less common markers
- INSM1 (Insulinoma-associated Protein 1).[2]
- NSE.
- CD57.
- PGP9.5.
See also
References
- ↑ McCluggage, WG.; Kennedy, K.; Busam, KJ. (Apr 2010). "An immunohistochemical study of cervical neuroendocrine carcinomas: Neoplasms that are commonly TTF1 positive and which may express CK20 and P63.". Am J Surg Pathol 34 (4): 525-32. doi:10.1097/PAS.0b013e3181d1d457. PMID 20182342.
- ↑ Sakakibara R, Kobayashi M, Takahashi N, Inamura K, Ninomiya H, Wakejima R, Kitazono S, Yanagitani N, Horiike A, Ichinose J, Matsuura Y, Nakao M, Mun M, Nishio M, Okumura S, Motoi N, Ito T, Miyazaki Y, Inase N, Ishikawa Y (June 2020). "Insulinoma-associated Protein 1 (INSM1) Is a Better Marker for the Diagnosis and Prognosis Estimation of Small Cell Lung Carcinoma Than Neuroendocrine Phenotype Markers Such as Chromogranin A, Synaptophysin, and CD56". Am J Surg Pathol 44 (6): 757–764. doi:10.1097/PAS.0000000000001444. PMID 32118626.