BAP1
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BAP1, an abbreviation of BRCA1-Associated Protein 1, is an immunostain that is used in the diagnosis of malignant mesothelioma.[1]
Loss of staining
- Malignant mesothelioma -ve[2] ~57%.[3]
Normal staining
- Well-differentiated papillary mesothelial tumour - retained (normal) nuclear staining.[4]
See also
References
- ↑ "BAP1: Not just a BRCA1-associated protein". Cancer Treat Rev 90: 102091. November 2020. doi:10.1016/j.ctrv.2020.102091. PMC 7655689. PMID 32877777. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655689/.
- ↑ Pulford E, Huilgol K, Moffat D, Henderson DW, Klebe S (2017). "Malignant Mesothelioma, BAP1 Immunohistochemistry, and VEGFA: Does BAP1 Have Potential for Early Diagnosis and Assessment of Prognosis?". Dis Markers 2017: 1310478. doi:10.1155/2017/1310478. PMC 5612603. PMID 29085180. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612603/.
- ↑ Andrici J, Sheen A, Sioson L, Wardell K, Clarkson A, Watson N, Ahadi MS, Farzin M, Toon CW, Gill AJ (October 2015). "Loss of expression of BAP1 is a useful adjunct, which strongly supports the diagnosis of mesothelioma in effusion cytology". Mod Pathol 28 (10): 1360–8. doi:10.1038/modpathol.2015.87. PMC 4761613. PMID 26226841. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761613/.
- ↑ Churg A, Galateau-Salle F (October 2022). "Well differentiated papillary mesothelial tumor: a new name and new problems". Mod Pathol 35 (10): 1327–1333. doi:10.1038/s41379-022-01082-y. PMID 35440764.